The Film Noir and Femme Fatale looks are personal favorites. For those shots, I often try to drop down that polished digital look in favor of the look of grain and/or chemically processed color. B/W and sepia tones add a little mystery, too. But recently, I opted for a straight-up shot where the feel was created in-camera.
I used a couple of Alien Bees with only the standard reflectors attached. And some flat "V" cards/panels (black side) to flag and direct the light as well as fake a sense of "environment" in an otherwise white, natural light-filled room. Below is the general idea of the setup I used.
Strobe output settings were adjusted without a flash meter; I setup one light, took a test shot, adjusted and did the same for the other. In these cases, a flash meter might help, but with a little experience you can get to your desired exposure just as quick using this method.
Here is a B/W version from the set with a little grain added, and a tilt reminiscent of some noir scenes. This perhaps gives us a slightly more old Hollywood look.